Shannen Doherty,” her publicist Leslie Sloane said. “She lost her battle with cancer after many years of fighting the disease.”

Doherty rose to fame in 1990 as Brenda Walsh on “Beverly Hills, 90210,” portraying a girl navigating life in Beverly Hills with her twin brother, Brandon. The show was a massive hit, addressing issues like drug abuse and racism, and Doherty became a central figure of media scrutiny. She left the show after four seasons amid rumors of on-set conflicts. Doherty later starred in “Charmed” as Prue Halliwell, a witch fighting evil alongside her sisters. She directed several episodes before leaving the series at the end of its third season. Born in Memphis, Tennessee, Doherty began her career as a child actor, appearing in “Father Murphy” and “Little House on the Prairie.” She also starred in films like “Heathers” and Kevin Smith’s “Mallrats.” Diagnosed with breast cancer in 2015, Doherty was initially in remission but the cancer returned in 2019. She continued working and hosted the podcast “Let’s Be Clear With Shannen Doherty.” She married photographer Kurt Iswarienko in 2011, and they filed for divorce in 2023.