In 2005, George and his wife Ann were admitted to Cedars-Sinai Medical Center under a false name. George was admitted with a kidney, but Ann was optimistic about his life, while George worried about their daughter’s future.

George Lopez and Ann Lopez divorced after 17 years together in 2010. George admitted to cheating on Ann during their marriage, and the couple faced backlash for ending their marriage. In a CNN interview, George admitted he deserved the backlash and that he and Ann seemed like the ultimate couple. In a TikTok video, Ann pointed out George’s role in breaking up with her. George later appeared on “The View” in January 2023, discussing his real-life family drama “Lopez vs. Lopez.” He admitted he didn’t want to open up about his personal life but needed to take accountability for his family’s fall apart. George and Ann went to therapy together to work on their issues. Despite the split, the ex-spouses remain cordial and hold each other dear.