She is most known for her role as Gabrielle Solis on the ABC television series Desperate Housewives, which ran from 2004 to 2012, and for which she received a Golden Globe nomination and won two Screen Actors Guild Awards with the cast.

Thanks to her acting works she has won three ALMA Awards, two People’s Choice Awards a Teen Choice Awards; Longoria has also appeared in The Sentinel (2006), Over Her Dead Body (2008), For Greater Glory (2012), Frontera (2014), Lowriders (2016), and Overboard (2018), later winning the Imagen Awards for Best Actress Film.